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Slowly release the water, letting it trickle down the side

Both methods have their perks, but we need more research to know which one wins the prize

The cells were cultured in Ultra-Low-Attachment plates (ULA) (Thermo Scientific) in PrimNeuS media ( 4.1.3 Mice and in vivo experiments All animal experiments were approved by The Institute of Cancer Research Animal Welfare and Ethical Review Body and performed in accordance with the UK Home Office Animals (Scientific Procedures) Act 1986, the UK National Cancer Research Institute guidelines for the welfare of animals in cancer research and the ARRIVE (animal research: reporting in-vivo experiments) guidelines

Turn the vial upside down so when you puncture the rubber membrane the needle is pointing up