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GLP-1RA reduces steatosis and improves mitochondrial function and survival of primary human hepatocytes in vitro by reducing apoptosis and fatty acid-induced endoplasmic reticulum (ER) stress, and inducing autophagy of free fatty acids (FFAs) in treated cells ( PPAR , ACSL1, ApoB , and SHP1 ( in vivo and in vitro studies have shown that liraglutide treatment can ameliorate hepatic lipid accumulation by activating AMPK ( 4.3 Limitation To the best of our knowledge, only a few umbrella reviews have evaluated the efficacy and safety of GLP-1 RAs in MASLD