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However, since the differences in total GSH conjugation activity catalyzed by these allelic variants are not higher than 30 %, the differences in inactivation of reactive intermediates by hGSTP1-1 are not likely to be a major factor in determining interindividual difference in susceptibility to adverse drug reactions induced by the drugs studied [34]

Silvestro says

However, you must be in good health, have stable blood sugar levels, and not be experiencing significant side effects like nausea or dehydration at the time of donation

Further mutants are obviously necessary to decipher the exact role of Tyr110 and to precisely map the glutathione interaction sites in future studies