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A common approach goes something like: gather some data, start your intervention, measure again, and repeat until you are satisfied that something is working or isnt

As we explained in the CY 2005 OPPS final rule with comment period (69 FR 65775), we generally use the lowest APC payment rate applicable for use with the nominated device when we assess whether a device meets the cost significance criterion, thus increasing the probability the device will pass the cost significance test