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The approval was based on results from the phase 3 SURMOUNT-1 and SURMOUNT-2 trials

Treg cells may enhance their dependence on extracellular fatty acids to fulfill the metabolic requirements for lipid synthesis

49 However, an interim analysis at 72 weeks of a phase 3 trial of semaglutide 2.4 mg once weekly for MASH showed histological improvements, including resolution of fibrosis, reduction of liver fibrosis and resolution of steatohepatitis in a significant number of patients

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