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Cancer Commun 2018;38:12
These cross-links are not easily reparable and may be lethal to the plant cell, if not repaired in time before commencement of critical cellular processes like replication or transcription
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The pathophysiology of DOX-induced POI is complex, but numerous factors have been proposed to be linked to the onset and development of ovarian dysfunction, including free radical-mediated lipid peroxidation, oxidative stress, mitochondrial malfunction, increased proinflammatory release of cytokines, and granulosa cell apoptosis 12,13,14
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