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The combination of Semaglutide and Wellbutrin for patients presents an intriguing prospect, particularly for those dealing with concurrent issues such as obesity, type 2 diabetes, and depression

Evidence on tapering strategies is limited

Although the data in this study cannot be extrapolated directly to humans, it does shed some light on potentially important physiologic effects of the medication. The decrease in lean mass with GLP-1 use was associated with a lesser decrease in skeletal muscle mass and a greater decrease in the size of metabolically active organs such as the liver