Clinical trials have shown HbA1c reductions of up to 2.4% and body weight losses of up to 22.5%, with improvements in insulin sensitivity, lipid metabolism, and cardiometabolic markers 2,3
Tirzepatide therapy helps you eat less, control your blood sugar, and digest food more slowly, which ultimately helps you lose weight by reducing the number of calories you take in and encouraging your body to burn stored fat.
FLOW trial stopped early due to evidence of renal protection with semaglutide
On the other hand data from the Diabetes Prevention Program study of 3234 pre-diabetic subjects over an average of 2.8 years who were randomized to receive placebo, metformin (850 mg bid), or lifestyle intervention, indicated that although both metformin and lifestyle changes were effective in reducing the risk of developing diabetes, lifestyle intervention was more effective ( Since both exercise and metformin can improve glycemic control and since both mediate their effects via the activation of AMPK, this suggests that there should be at least an additive effect when metformin use is combined with exercise
