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The compounds quinolinium scaffold confers membrane permeability that enables intracellular enzyme inhibition, distinguishing it from earlier polar NNMT inhibitor scaffolds that did not effectively enter intact cells

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Importantly, the Fenton reaction based on the release of Mn ions and the inactivation of GPX4 accompanied by accumulation of lipid peroxidation and ROS that can further sensitize Cuproptosis [173,174,175]

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Molecules , 25

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