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Reasons for increased needs in athletes: stress related to physical demands (Yes, training is stress on the body!) biological adaptations increased turnover (athletes use more vitamins) genetics reduced absorption Early detection of deficiency can be difficult to recognize because symptoms overlap with many other conditions and are normalized in athletes

Interestingly, an antagonist of MC-4R had an opposite effect, suggesting that MC-4R activation by MT-2 influences preference for alcohol

This can lead to an undersupply of ATP and further contribute to oxidative stress, ultimately producing the cognitive deficits observed in chemobrain

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