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Within this pathway, acetyl-CoA is first converted to malonyl-CoA by ACC, followed by transformation into palmitate by FASN [62, 63]

PDRN also inhibits microphthalmia-associated transcription factor (MITF), which reduces melanin synthesis

Surgery is usually reserved for patients who have very large goitres (enlarged thyroid glands) that cause compression symptoms such as difficulty breathing or swallowing, who have eye problems due to Graves disease (Graves ophthalmopathy), who have suspicious nodules or cancer in the thyroid gland, or who are not suitable for or refuse anti-thyroid drugs or radioactive iodine therapy

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