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When to seek medical advice red-flag symptoms Patients or trial participants should seek prompt medical advice if they experience any of the following: Persistent or severe vomiting that prevents adequate fluid intake Signs of dehydration , such as dizziness, dark urine, or confusion note that dehydration can precipitate acute kidney injury and requires urgent assessment [11] [12] Severe or persistent upper abdominal pain , particularly pain that radiates to the back, which may be accompanied by nausea, vomiting, or fever this may indicate acute pancreatitis or gallbladder disease, both of which are recognised risks with GLP-1-based therapies and require urgent medical review [11] [17] Jaundice (yellowing of the skin or whites of the eyes) Significant unintentional weight loss beyond what is expected Any new or unexpected symptoms that cause concern For urgent advice, contact NHS 111

Only studies were included in this review that aimed at pulmonary drug delivery for treatment of COVID-19

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