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Another study showed that over a 6-week period, saffron (30 mg/day) was as effective as imipramine (100 mg/day) in reducing depressive symptoms

for instance, case reports have demonstrated survival after a 25 g overdose [42] , and current guidelines in the United States and Canada indicate a high-risk ingestion to be ingestion of at least 30 g of APAP [43]

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In environments where endogenous glutathione is severely depletedsuch as during a massive inflammatory flare, a viral cytokine storm, or an MCAS reactionthe free sulfhydryl group (-SH) on the NAC molecule allows it to act as a direct scavenger