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According to the results of the analysis, the three metabolites generated by the intestinal microbiota from L-carnitine (TMAO, -butyrobetaine and crotonobetaine) were partly responsible for the unfavourable association with the consumption of unprocessed red meat, total meat, and foods of animal origin, with proportions mediating 10.6%, 7.8%, and 9.2% of the risk, respectively

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Moreover, many studies rely on in vitro or animal models, which may not fully replicate human bone metabolism or disease complexity