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In the context of Traditional Chinese Medicine (TCM), Curcuma longa was included as one of the herbs in the tumor-shrinking decoction, which is currently under phase-III clinical trials ( Curcuma longa was also added to tonify qi as UF is believed to be a product of vital energy deficiency and stasis of blood according to TCM theories ( Curcuma longa is also used in Ayurveda as the main ingredient for the formulation Haridra Khanda , which appeared to be effective in relieving the symptoms and size of UF in a case series ( The ability of turmeric extract in protecting the uterine myometrium from oxidative damage-induced UF has been reported ( The antioxidant activity may be attributed to curcumin, the main polyphenol and active compound present in Curcuma longa which has the ability to increase the level of antioxidant enzymes, which include catalase, superoxide dismutase, and glutathione peroxidase ( In vitro study with curcumin on Eker rat-derived uterine leiomyoma cell lines (ELT-3) showed the ability of curcumin to inhibit leiomyoma cell proliferation while increasing apoptosis by acting as a PPAR ligand ( Apoptosis of uterine leiomyoma cells was also stimulated by the expression of caspase-3, an important mediator for apoptosis, and by caspase-9, an initiator of apoptosis ( Leiomyoma is a benign tumor with excessive ECM production