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Description

The combination of CB-839 and azacytidine (AZA) was found to be synergistic in a single-arm, open-label, phase 1b/2 study conducted in patients diagnosed with advanced myelodysplastic syndromes (MDS)

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In endothelial cells, a 24 h exposure to NAC resulted in the disruption of tight junctions due to a reduction in occludin, delocalization of claudin-5, and an increase in neuronal nitric oxide synthase (nNOS) expression, which led to increased permeability

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10.1074/jbc.M115.680090 11 CobleyJ

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