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Y1-R-mediated effects on pancreatic islets Our experiments were also designed to determine whether peptides that are efficacious at lower concentrations and/or those that promote modified internalization/-arrestin recruitment might be capable of sustaining the beneficial effects beyond those currently observed while also reducing the frequency of adverse events

This once-weekly cadence is one of the practical advantages of the long half-life: a single anchored injection covers the entire week, and there is no daily-dosing burden to maintain