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After IGF-1 binds to its ligand, a series of phosphorylation events leading to activation of insulin receptor substrates, mitogen-activated protein kinase (MAPK), and phosphoinositide 3-kinase/protein kinase B (PI3K-Akt) lead to various intracellular processes [21]

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LZ: Conceptualization, Data curation, Formal Analysis, Funding acquisition, Investigation, Writing original draft