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The STEP trial program examining higher-dose semaglutide (2.4 mg weekly) for weight management demonstrated mean weight loss of 12% to 15% over 68 weeks in adults with obesity, significantly exceeding placebo

On the other hand, 90-min intraduodenal infusions of primarily long-chain FAs (LCFAs) in men resulted in an increased glucagon response, although the increase was small compared with responses to protein infusion (42)

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