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If Cosmetic Irritation Occurs Reduce cosmetic application frequency Lower formulation concentration Discontinue cosmetic use if irritation persists Cosmetic Application Considerations Patch testing is recommended before larger cosmetic application areas Avoid direct contact with eyes Avoid application to broken, compromised, or irritated skin Lower introductory concentrations are commonly preferred for sensitive-skin formulations For Cosmetic Formulation and Research Use Only Not for injection or human consumption

J Mol Med 84 , 10471054 (2006)