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Only the second phase in biphasic elimination is relevant to pharmacologic action

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In addition to the salutary effect on the lower doses of neuroleptics, an even stronger beneficial anticataleptic effect of NaBPC157 appears with a higher dosage of both neuroleptics observed with both g and ng doses of NaBPC157

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Acknowledgements This work was supported by the National Key R&D Program of China (2022YFD1600505)

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The involved signaling pathways include increased pAMPK, SIRT1, fibroblast growth factor-21, and decreased ChREBP

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