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They modulate immune responses and reduce chronic inflammation that impairs cellular repair

Exercise, Metformin, and Healthspan Exercise activates AMPK, which in turn enhances glucose uptake into muscle and improves insulin sensitivity thus helping to offset the negative effects of obesity, diabetes and cardiovascular disease and thereby reducing morbidity and improving healthspan (197)

Sequential intensification of metformin treatment in type 2 diabetes with liraglutide followed by randomized addition of basal insulin prompted by A1c targets

Hirsch, MD Over the last several years, GLP-1s have gained popularity and become household names