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230 In summary, these findings underscore the significant role of lactylation in regulating metabolism, epigenetics, immunosuppression, cell death, stemness, and invasion and metastasis of cancer cells, offering valuable insights into the molecular mechanisms through which lactylation governs cancers and paving the way for the development of cancer intervention strategies that target lactylation

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The catalytic serine S630 falls within the pentapeptide sequence Gly628-X-Ser630-Tyr631-Gly632, which is highly conserved across the / hydrolase protein family