The receptor exhibits diverse tissue expression but is most notably found in the pancreatic beta-cells, stomach, duodenum, vagal afferent nerves, lungs and in the CNS [23, 24]
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Controls exhibit low activation of detrimental pathways and preserved protective mechanisms (e.g., antioxidant capacity, plasmalogens, CIRS), whereas patients display distinct combinatorial patterns, most frequently driven by phospholipid remodeling and lipotoxicity, with additional contributions from the acute phase inflammatory response and decreased antioxidant defenses in some cases
Yes, it is generally suitable for most skin types