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CuPT inhibits cancer cell growth by targeting active sites of 19S DUBs (UCHL5 and USP14), leading to accumulation of both total and K48-linked ubiquitinated proteins (e.g., CDKN1A, CDKN1B, BAX, and NFKBIA) and GFPu (a surrogate proteasome substrate) (Liu et al., 2014b)

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Priftis A, Stagos D, Konstantinopoulos K, Tsitsimpikou C, Spandidos DA, Tsatsakis AM, Tzatzarakis MN, Kouretas D

Following traumatic brain injury (TBI), large quantities of S100B protein released from astrocytes and damaged neurons act as typical DAMPs