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Mitochondria contain 1015% of total GSH, and the concentration of GSH in mitochondria is similar to that of the cytoplasmic matrix [57, 58]

This small molecule, with a molecular weight of approximately 403.9 Da for the free peptide (or ~467 Da as the copper complex), is found at concentrations of approximately 200 ng/mL in young adults, declining significantly with age

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A sustained decrease in ATP levels leads to a relative increase in the intracellular AMP content, and blocking ATP production triggers cellular senescence, which is demonstrated by an increase in the expression levels of two proteins, p16INK4A and p21CIP1/WAF1 [93]