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NICE guidance acknowledges the role of GLP-1 receptor agonists like semaglutide as treatment options for type 2 diabetes when metformin alone provides insufficient glycaemic control, particularly in patients where weight loss would be beneficial

Demethylzeylasteral targets lactate by inhibiting histone lactylation to suppress the tumorigenicity of liver cancer stem cells

ROS include superoxide (O 2), nitric oxide (NO), hydroxyl radical (-0H), hydroperoxyl radical (O 2 H), hydrogen peroxide (H 2 O 2 ), and singlet oxygen (28)

Instead, it inhibits an enzyme called NNMT, which shifts cell metabolism toward fat oxidation and muscle preservation