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Aetnas common clinical criteria include: At least 18 years of age or older A BMI of 30 or greater or 27 or greater plus at least one comorbidity Participation in a comprehensive lifestyle program for at least 6 months before starting medication

This recommendation may need adjustment for older adults or those with certain medical conditions such as chronic kidney disease, where protein requirements differ

For example, the Benadryl label may advise against using it with other medications that cause drowsiness

Foundayo (Orforglipron) For those seeking flexibility, Foundayo offers a once-daily pill approved in 2026 that can be consumed at any time, with or without food