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3.3.3 Receptors mediated mitophagy activators Panax notoginseng saponins (PNS), the primary ingredient from Panax notoginseng, exhibits extensive therapeutic effects in cardiovascular diseases (Liu et al., 2014), lung cancer (Yang et al., 2016) and diabetes (Uzayisenga et al., 2014)

76 However, our functional findings in vivo and ex vivo suggest that HCN channels are not required for the GLP-1-induced increase in heart rate

However, gastrointestinal adverse effects (nausea, vomiting, diarrhea, constipation), unrealistic expectations, injection fatigue, drug availability, and inadequate counselling may also contribute