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While the published study focused primarily on SGLT2is and reported improvements in DHEAS and menstrual irregularity, our meta-analysis included a broader range of interventions (GLP-1 RAs alone and in combination) and found more pronounced hormonal benefits, such as significant reductions in FAI and testosterone with SGLT2is, outperforming GLP-1 RAs in these aspects

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Body composition affects mood through multiple pathways, including inflammatory signaling from visceral adipose tissue, self-image, and hormonal regulation