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They release a cocktail of signaling molecules including TNF-alpha, interleukin-1, interleukin-6, bone morphogenetic proteins (BMPs), platelet-derived growth factor (PDGF), transforming growth factor beta (TGF-beta), and vascular endothelial growth factor (VEGF)

As a fragment of growth hormone that specifically targets fat metabolism, it appears to avoid many of the side effects associated with full growth hormone therapy, such as joint pain, fluid retention, and effects on glucose metabolism

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Other Metabolic Benefits In the T2D trial, there were also dose-response reductions in HbA1c: retatrutide 12 mg reduced HbA1c by 2.16% at 36 weeks, corresponding to an estimated difference from dulaglutide 1.5 mg of -0.80% (95% CI: -1.16, -0.44)