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Full-length human growth hormone binds to growth hormone receptors distributed throughout the body, triggering a cascade of effects including stimulation of IGF-1 production in the liver, alterations in glucose and insulin metabolism, protein synthesis in muscle tissue, bone growth and remodeling, organ enlargement with prolonged use, and fluid retention

Absorption across the gut epithelium, first-pass liver metabolism, and systemic distribution are all separate steps that determine whether an orally administered compound reaches target tissues at meaningful concentrations

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