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The UK CPRD data were linked to the Hospital Episode Statistics Admitted Patient Care (HES APC) and the Office for National Statistics (ONS) databases, but the linkage was available only in a subset of individuals

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The calculation requires four inputs: annual net revenues under exclusivity for each remaining year, post-LOE revenue trajectory (typically modeled as a percentage of pre-LOE revenues declining on a defined schedule), the date of LOE for each IP protection layer, and the discount rate

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