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Wu, "Effects of GHK-Cu on MMP and TIMP expression, collagen and elastin production, and facial wrinkle parameters," J

Studies indicate dual (OR = 3.258) or triple (OR = 8.226) anti-obesity therapy substantially elevates risk potential compared to monotherapy

All patients were required to have continuous enrollment of at least 12 months before cohort entry and meet eligibility criteria for one of the five cohort studies defined below (study design diagrams depicted in Supplementary Figs