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Acknowledgements This work was supported by the US National Institutes of Health (NIH) grant (R35 CA197588), Stand Up to CancerAmerican Association for Cancer Research grant (SU2C-AACR-DT22-17), and the Damon Runyon Cancer Research Foundation
This corresponds to dose multiples of 9 and 19.5 times, respectively, the maximum recommended human dose (MRHD) of 10 mg/day for amlodipine and 320 mg/day for valsartan (based on body surface area and considering a 60 kg patient)
Another important issue associated with decreased immune function in older adults is micronutrient deficiencies, as well as the less pronounced form, namely micronutrient inadequacies, which represent distinct forms of malnutrition [42, 43]
It is important to work with clinicians who understand these protocols
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