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2 Materials and Methods 2.1 Subject Recruitment In total, 22 Chinese patients with MS, including 20 RRMS and two PPMS cases, who were diagnosed based on the revised version of the 2005 McDonald criteria ( Table 1 )

Despite advances in antimicrobial therapy and supportive care, sepsis continues to result in high morbidity and mortality, with an estimated 48.9 million cases and 11 million deaths worldwide in 2017, accounting for nearly 20% of all global mortality, disproportionately affecting low- and middle-income countries (Rudd et al., 2020)

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