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Biomarkers: Multiple blood and CSF biomarkers were collected (see figure below) - the CSF biomarkers were only in a subset of patients (199) who agreed to participate in a substudy
Shan et al
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It works by: Slowing gastric emptying , which prolongs feelings of fullness after eating Reducing appetite through effects on brain regions that regulate hunger Improving glycaemic control by enhancing insulin secretion when blood glucose is elevated Reducing glucagon secretion , which helps prevent excessive glucose production by the liver The medication is administered as a once-weekly subcutaneous injection, with doses gradually increased over 16-20 weeks to the maintenance dose of 2.4 mg weekly (though some patients may remain on 1.7 mg if the higher dose is not tolerated)
Subgroup analysis revealed that subcutaneous injection of semaglutide is more likely to cause adverse events related to the endocrine system compared to oral administration
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