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In the case of organic compounds, biotransformation steps are often necessary and their nature, mechanism(s), responsible enzymes and related polymorphisms are well characterized and the respective role in determining individual sensitivity to the effects of exposure at different levels is a well-established field of investigation

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doi: 10.1038/s41568-018-0007-6 22 ZhaoZChenXDowbajAMSljukicABratlieKLinLet al

Organelle clearance during maturation of erythrocytes is associated with the loss of components of the cell death machinery A growing number of studies indicate that mature erythrocytes have a precisely structured RCD machinery comprising of several lethal subroutines with clearly defined molecular mechanisms