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Nat Med 2001

While not definitive, these results support closer attention to this drug class as clinical trials move forward

Most importantly, the climate benefits of reduced morbidity, improved mobility, and increased life expectancy associated with effective obesity treatment vastly outweigh any theoretical carbon perturbation described here

Where appetite is the dominant driver of weight: the GLP-1/GIP dual mechanism of tirzepatide already addresses appetite and satiety powerfully, and adding a third receptor may offer diminishing marginal benefit for this specific lever