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These are consistent with the mechanism of action slowing gastric emptying affects digestion, and central appetite suppression can cause nausea, particularly during the early stages of treatment and dose escalation

score 3: large confluent complete infarcts (4060% of area affected)

Intracellular reactive oxygen species production may cause cellular damage ( Reference Streck, Vieira and Wannmacher 9 ) and disorders of the antioxidant defence system ( Reference Blundell, Jones and Rose 12 ) , demonstrating a mechanistic connection between hyperhomocysteinaemia, oxidative stress and disease

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