Deciphering these divergent mechanisms is essential for developing targeted, pathology-specific antioxidant therapies [185]
Increased erythrocyte clearance has been associated with eryptosis in thalassemia [232], hereditary spherocytosis [232], sickle cell disease [233], and glucose-6-phosphate dehydrogenase deficiency [234]
Doi: Ishihara K, Amano K, Takaki E, Ebrahim AS, Shimohata A, Shibazaki N, Inoue I et al (2009) Increased Lipid Peroxidation in Downs Syndrome Mouse Models
First, GSH is vital for normal cellular functions, including detoxification and protection against oxidative stress, so systemic depletion can damage healthy tissues such as the liver, kidneys, and bone marrow