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Patients who receive a combination of anesthetic and steroid medication may notice a slight increase in pain after the injection as the numbing medicine wears off and the cortisone starts to take effect

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This creates a regional pattern that does not resemble the results obtained with any other serotonergic drug using this method. Why This Matters This nigrostriatal focus is mechanistically intriguing because these regions are heavily involved in motor control, reward processing, and motivation