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Moreover, excessive ROS is thought to underlie many of the skeletal phenotypes associated with aging and sex steroid deficiency in mice and humans

Ali Rezaie, Medical Director of Gastroenterology Motility at Cedars-Sinai Medical Center, emphasized the need for context, noting that while the relative risk increases by 33%, the absolute risk remains low at 0.2%

However, these recommendations lack sufficient evaluation of the risk-benefit profile in HS-specific populations, thereby justifying further safety studies

Adeva-Andany MM, Carneiro-Freire N, Seco-Filgueira M, Fernndez-Fernndez C, Mourio-Bayolo D (2019) Mitochondrial -oxidation of saturated fatty acids in humans