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During the blinded data review an indication of period effect was noted and properly registered as follow up action according to the Statistical Analysis Plan of the trial protocol

At the core of this protective adaptation lies the upregulation of cystine/glutamate antiporter solute carrier family 7 member 11 (SLC7A11), driven by the inactivation of key tumor suppressors including TP53, BRCA1 associated protein 1 and alternate reading frame (16,135)

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