Although transepithelial electrical resistance and the movement of marker solutes is frequently used to measure paracellular permeability, only a small number of publications have directly documented paracellular movement of solutes by autoradiography, in vivo confocal microscopy, or electron microscopy [25,26,27,28] whereas for most cases, the differentiation of paracellular from transcellular movement has been indirect [23, 29]
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While these pathways are theoretically relevant to soft-tissue recovery, orthopaedic-specific evidence remains minimal
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