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- In the United States, Semax is classed as a research peptide and does not hold approval for human use

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Other symptoms include: Chest pain when taking a breath (pleurisy) Dry eyes and mouth (Sjgren syndrome) Eye burning, itching, and discharge Nodules under the skin (most often a sign of more severe disease) Numbness, tingling, or burning in the hands and feet Sleep difficulties The diagnosis of RA is made when: You have pain and swelling in 3 or more joints