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In a study of 325 individuals with MASLD, advanced fibrosis was associated with a 5% faster pace of aging, as measured by DunedinPACE, and a 10% reduction in telomere length, captured by DNAmTL, compared to those without fibrosis 17

However, notably in a PCP model of schizophrenia, only 30 mg/kg, but not 3 or 10 mg/kg, rescued defects in hyperlocomotion and PPI, in stark contrast to cell culture models where lower models were more beneficial (Shirai et al., 2012)

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20,21,22,23,24 Multiple factors have been associated with discontinuation, including cost, insurance type, comorbidities, and absence of type 2 diabetes