Transporter Endogenous Substrates References MRP1 GSH conjugates, cysteinyl leukotrienes, glucuronic acid conjugates, bilirubin, estradiol, sulfate conjugates, bile salts, sulfated steroids, GSH, GSSG [82,107,108] MRP2 GSH conjugates, cysteinyl leukotrienes, glucuronic acid conjugates, bilirubin, estradiol, sulfate conjugates, bile salts, sulfated steroids, GSH, GSSG [82,107,109,110] MRP3 GSH conjugates, cysteinyl leukotrienes, glucuronic acid conjugates, bilirubin, estradiol, sulfate conjugates, bile salts [82,107,111] MRP4 GSH conjugates, cysteinyl leukotrienes, glucuronic acid conjugates, estradiol, sulfate conjugates, sulfate conjugates, cyclic nucleotides, bile salts [82,111113] MRP5 GSH conjugates, glucuronic acid conjugates, cyclic nucleotides, GSH [82,111,114] MRP6 GSH conjugates, cysteinyl leukotrienes [82,115] MRP7 GSH conjugates, cysteinyl leukotrienes, glucuronic acid conjugates, estradiol [82,116] MRP8 GSH conjugates, cysteinyl leukotrienes, glucuronic acid conjugates, estradiol, sulfate conjugates, cyclic nucleotides, GSH [82,116] MRP9 Unknown, but not drug conjugates or other organic anions [117] 4.2
10.1093/cid/cix1127 Clin
Ritalin sits between the two
Semaglutide: What It Is and How It Works Semaglutide is the active ingredient in both Ozempic (approved for type 2 diabetes) and Wegovy (approved specifically for chronic weight management)
