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Other contributing factors include sleep disturbances (which may worsen with gastrointestinal symptoms), medication interactions (particularly with sedatives, opioids, or anticholinergics), and the psychological stress of lifestyle changes
The challenges: GLP-1s can also: Slow gastric emptying, which increases operative risks Cause slower wound healing if nutritional intake is low Lead to muscle loss, which can reduce recovery strength Continue to suppress appetite during a period where nutrition is critical Some surgeons require: A pause before surgery (often 24 weeks) Evidence of stable nutrition A personalised post-operative plan to avoid nausea and ensure adequate protein intake In short, GLP-1s can help, but they must be used mindfully and usually require a pre- and post-surgery strategy with your healthcare provider
In healthy individuals GLP-1 and GIP together add up to about 60% of postprandial insulin secretion
Besides lowering blood glucose and reducing weight (incredibly visceral fat), GLP-1R agonists can also lower blood pressure, improve blood lipid disorder, and reduce fatty liver (140)
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