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Furthermore, IR in the liver and adipose tissue has been regarded as a crucial driver of NASH morbidity and mortality (120)

Ozempic should not be used by anyone who: Has a personal or family history of thyroid cancer Has multiple endocrine neoplasia syndrome type 2 (MEN2) Has pancreatitis Is currently pregnant or breastfeeding Who shouldnt take metformin

Glucose-6-phosphatase (G6Pase) contributes to hyperglycemia in diabetes mellitus and regulates the rate-limiting steps in hepatic gluconeogenic flux (Herling et al., 1998)